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What is iLINCS?
iLINCS Paper
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Workflows
Analyze a drug signature and find other drugs with similar signatures
Analyze LINCS transcriptomic and proteomic datasets
Analyze genes against LINCS data
Tasks
Signatures
Search for a signature
Navigating signature landing page
Find signatures with pharmacological actions
Datasets
Search for LINCS Dataset
Navigating dataset landing page
Create a signature
Adjusting number of genes in a signature
Perform a multi-group analysis
Genes
Query a list of genes in LINCS dataset
Use Cases
Identify sets of drugs with similar transcriptional signatures
Identifying chemical perturbagens emulating genetic perturbation of MTOR protein
Mechanism of action analysis via connection to genetic perturbation signatures
Proteo-genomics analysis of cancer driver events in breast cancer
Reversing Estrogen Receptor (ER) signature profile
Reversing MTOR loss-of-function signature profile
What are my GENES doing in LINCS dataset?
F A Q
What is a signature
What is connectivity map
How signature connectivity analysis is performed in iLINCS
How perturbagen connectivity analysis is performed in iLINCS
Why is my signature correlation calculation different from iLINCS pre-calculated signature correlations?
How to construct signatures from iLINCS datasets
How to use iLINCS APIs in R
Datasets
LINCS
TCGA
GDS
Signature Libraries
LINCS consensus (CGS) gene knockdown signatures
Overview of precomputed signature libraries
Cancer Therapeutics Response Signatures
Connectivity Map signatures
Disease related signatures
DrugMatrix signatures
ENCODE transcription factor binding signatures
LINCS chemical perturbagen signatures
LINCS gene overexpression signatures
LINCS targeted proteomics signatures
Transcriptional signatures from EBI Expression Atlas
Integrated External Analysis Tools
PiNET
Morpheus heatmap
Enrichr
DAVID
ToppFun
GeneMANIA
Reactome
L1000CDS2
L1000FWD
X2K
Assays
GCP
RPPA
L1000
P100
RNA-seq
Identifying chemical perturbagens emulating genetic perturbation of MTOR protein
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Last updated on 25th Apr 2024
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